CORDIS Project
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This project investigates how lipid nanoparticles can be used to reprogram immune cells in tumors to enhance cancer treatment. It focuses on understanding the interaction between these nanoparticles and myeloid cells to improve immune responses against tumors.
Persistent inflammation during tumorigenesis drives myelopoiesis.
Consequently, monocytes and granulocytes/neutrophils infiltrate the tumor microenvironment (TME) and differentiate into tumor-associated macrophages or myeloid-derived suppressor cells, creating an immune-suppressive microenvironment that hampers cytotoxic T cell function and limits immune checkpoint inhibitor (ICI) efficacy. ‘Reprogramming’ myeloid cells to adopt pro-inflammatory phenotypes is promising to restore immune function…
UNIVERSITEIT GENT
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