CORDIS Project
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This project explores the use of engineered non-pathogenic bacteria to dissolve biofilms associated with ventilator-associated pneumonia. It aims to confirm the safety and efficacy of this approach in animal models, potentially leading to innovative treatments for respiratory infections.
Among 65-80% of human infections are associated to biofilms, especially in respiratory infections or those associated with catheters.
Endotracheal tube (ETT) biofilm is related to the development of ventilator-associated pneumonia (VAP), which occurs in 9–27% of all intubated patients.
Those ETT-biofilms are mainly formed by Pseudomonas aeruginosa and/or Staphylococcus aureus, forming a protective barrier against antibiotics and the host immune system.
The consequence of VAP is chronic inflammat…
FUNDACIO CENTRE DE REGULACIO GENOMICA
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