CORDIS Project
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This project investigates the role of oligodendrocytes in supporting axonal health and metabolism, beyond their function in myelination. It aims to explore how these cells contribute to neurological health and their potential impact on neurodegenerative diseases.
Myelin is made by highly specialized glial cells and enables fast axonal impulse propagation.
We havediscovered that oligodendrocytes in the CNS are, in addition to myelination, required for the integrity andsurvival of axons, independent of the presence or absence of myelin itself.
More recently, we found theunderlying mechanism and could show that glycolytic oligodendrocytes provide axons with pyruvate/lactate.These metabolites are transported through a system of myelinic nanochannels to the a…
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
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