CORDIS Project
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This project investigates the mechanisms behind anaphylaxis, a severe allergic reaction, focusing on the role of immunoglobulin G antibodies and various immune cells. It aims to develop a better understanding of anaphylaxis triggers and explore potential treatment strategies for drug-induced cases.
Anaphylaxis is a hyperacute allergic reaction of increasing incidence that can be of fatal consequence and that has no specific treatment.
Anaphylaxis is thought to rely on mechanisms involving mast cells that bear allergen-specific IgE and that release histamine when encountering allergen.
Clinical cases, however, report anaphylaxis in the absence of specific IgE or medical history of allergy.
We reported that murine models of anaphylaxis rely on IgG, rather than on IgE, that enable neutrophils…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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