CORDIS Project
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This project investigates the role of Myo18, a unique motor protein, in the cytoskeleton's structure and dynamics. It aims to understand how Myo18 interacts with Myo2, another motor protein, to influence force production and cell movement through structural and biophysical analyses.
The cytoskeleton is a complex protein web organised through the cell to provide structure and cell shape dynamics.
One critical and often overlooked component is Myo18, which is part of the myosin superfamily of motor proteins.
By interacting with actin, myosins canonically produce force through a series of conformational changes driven by the hydrolysis of ATP.
However, Myo18 appears not to cycle through the set of conformations found for other myosins due to its divergent sequence.
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