CORDIS Project
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This project investigates how myeloid cells, specifically dendritic cells and neutrophils, adapt their metabolism to different tissues in response to aging. By understanding these metabolic changes, the research aims to uncover how they affect immune functions and contribute to age-related immune dysfunction.
Myeloid cells, such as dendritic cells (DCs) and neutrophils, reside in various organs to respond to insults and are key to control immunity and inflammation.
However, their aberrant activities in the elderly can cause immunosenecence and inflammaging.
Different tissues comprise highly distinct milieus that impose context-dependent biochemical challenges on their resident cells, which further change when tissues age.
Yet, it is not known how DCs and neutrophils survive in their different homing…
FUNDACIO INSTITUT DE RECERCA BIOMEDICA (IRB BARCELONA)
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