CORDIS Project
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This project investigates the role of nicotinic acetylcholine receptors in prostate and colorectal cancer. It aims to identify specific receptor subunits, their impact on cancer cell behavior, and the potential influence of certain drugs on receptor expression and treatment resistance.
Nicotinic acetylcholine receptors (nAChRs) are transmembrane ligand gated ion channels composed of five subunits and encoded by 16 genes.
Depending on the subunit composition nAChRs have different properties and functions.
It is widely accepted that smoking tobacco is correlated with several types of cancers and that nicotine and tobacco-derived nitrosamines are known to activate nAChRs contributing to oncogenic processes.
To date the question of whether nAChRs contribute to the cellular malfunc…
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