CORDIS Project
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This project focuses on understanding the dynamics of membrane proteins using advanced spectroscopy techniques. It aims to improve analysis methods for hydrogen/deuterium exchange data and apply them to various membrane protein systems to gain insights into their functional dynamics.
Protein dynamics is essentially linked to protein function, aggregation, and folding.
Time-resolved spectroscopy is specially suited to reveal these dynamics, counterbalancing the static pure-structural information provided by X-ray crystallographic structures.
In equilibrium, protein conformation fluctuates, eventually visiting all possible higher-energy states in equilibrium with the ground state conformation.
For soluble proteins the dynamics of such fluctuations have been successfully detect…
UNIVERSITAT AUTONOMA DE BARCELONA
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