CORDIS Project
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The NanoALS project aims to develop a novel therapy for Amyotrophic Lateral Sclerosis by using gold and PLGA nanoparticles that are functionalized with antibodies to target misfolded SOD1 proteins. This approach seeks to prevent the spread of neurodegeneration by blocking the uptake of toxic proteins by surrounding cel…
As the life span of the population extends, the prevalence of neurodegenerative diseases is rapidly increasing representing a considerable impact for the quality of life and economy of many countries worldwide.
Most of these diseases, including Amyotrophic lateral sclerosis (ALS) are currently considered as proteopathies, where some proteins (SOD1 in the case of ALS) adopt misfolded conformations prone to aggregate and cause cellular toxicity and motor neuron death.
Moreover, these proteins are…
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