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NanoCHROMS investigates how physical forces affect chromatin structure within cells. By using advanced nanofabrication and microscopy techniques, the project aims to uncover the mechanisms behind cellular responses to mechanical stimuli, contributing to our understanding of gene expression and cancer development.
Cells respond to physical stimuli from their environment, drastically changing their chromatin organization.
Direct nuclear mechanotransduction affects cell behavior, but this mechanism is still not fully understood.
This unsolved link is due to the difficulty of finding tools to generate precise mechanical signals and observe changes in chromatin at the nanoscale level.NanoCHROMS aims to understand the effect of nuclear mechanotransduction on nuclear architecture.
We aim to characterize the mec…
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