CORDIS Project
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The project aims to enhance RNA nanoparticle drug delivery systems for cancer treatment by characterizing the protein corona that forms around these nanoparticles. Understanding these interactions will help optimize their effectiveness and safety in clinical applications.
In the past three decades, nanomedicine has emerged as a promising strategy in cancer treatment and has led to numerous proposed drug delivery systems.
Nanoparticles aim to improve selectivity towards cancer cells while reducing off-target effects and toxicity towards normal cells.
Among these systems, self-assembled RNA nanoparticles have been of great interest for drug delivery, because of their low cost, high yielding assembly and retained functionality.
Yet, challenges such as poor nuclease…
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