CORDIS Project
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This project explores the insulin-linked polymorphic region's role in insulin gene transcription. By studying various DNA sequences and their structures, it aims to understand how small molecules can influence insulin expression, potentially leading to new therapeutic approaches for diabetes.
The insulin-linked polymorphic region (ILPR) resides in the promoter region of the gene coding for insulin (INS).
This region consists of a 14-base pair tandem repeat DNA sequence of 5'-ACAGGGGTGTGGGG-3'/3'-TGTCCCCACACCCC-5' and is located 363 base pairs upstream of the transcription start site of insulin.
The insulin-linked polymorphic region can form non-canonical DNA secondary structures such as G-quadruplexes, i-motifs and hairpins.
Previous work at the UCL School of Pharmacy has shown that…
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