CORDIS Project
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The NCORe project investigates the role of chromatin organization in gene regulation and nuclear transport. It aims to understand how heterochromatin exclusion zones at nuclear pores influence chromatin structure and function, using advanced microscopy and molecular techniques.
Chromatin organization plays a crucial role in regulating DNA-related processes such as transcription, replication, and repair.
In most somatic cells, heterochromatin localizes at the nuclear periphery while euchromatin is broadly distributed within the nucleus.
This spatial organization is believed to mostly rely on the association of heterochromatin with the nuclear lamina, which in turn participates in gene repression.
In a striking contrast, the nuclear pore vicinity is always devoid of hete…
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
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