CORDIS Project
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This project investigates the structure of the complex formed by 6S RNA and the sigma 70 RNA polymerase, focusing on how 6S RNA regulates gene expression during bacterial growth phases. By using X-ray crystallography, the project aims to clarify the molecular mechanisms behind this regulation and the specificity of the…
It was a surprise of the last decade the large number of small, noncoding RNAs, which have been identified to play regulatory roles in the modulation of gene expression in all kingdoms of life.
The bacterial 6S RNA is a transcription regulator of the σ70-RNA polymerase holoenzyme during the stationary phase.
It has been shown that 6S binds with high affinity and specificity onto the σ70-RNAP and presumably blocks the sites of interaction of RNAP with DNA promoters.
It has also been shown that up…
DEMOCRITUS UNIVERSITY OF THRACE (DUTH)
DIMOKRITIO PANEPISTIMIO THRAKIS
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