CORDIS Project
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This project investigates the role of G protein-coupled receptors in Uveal Melanoma, focusing on the therapeutic potential of inhibiting Focal Adhesion Kinase to combat cancer growth. It aims to identify molecular factors that influence treatment response and develop targeted strategies to enhance therapy effectiveness…
G protein-coupled receptors (GPCRs) represent the largest family of cell surface proteins involved in signal transmission.
Nearly 30% of human cancers harbor mutations in GPCRs/G proteins.
Activating mutations in GNAQ and GNA11 have been discovered in 90% of Uveal Melanoma (UM).UM is the most common primary cancer of the eye in adults and to date there are no effective treatments. 50% of UM patients develop metastatic disease, which is refractory to current chemotherapies leading to patient deat…
UNIVERSITA DI PISA
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LOS ANGELES UCLA SANTA BARBARA UCSB DAVIS UCD RIVERSIDE UCR SAN DIEGO UCSD SANTA CRUZ UCSC IRVIN
United States, Berkeley
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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