CORDIS Project
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NEO-CIRC aims to improve the treatment of hypotension in newborns by evaluating the safety and efficacy of Dobutamine as a first-line therapy. The project will also develop better biomarkers and a suitable formulation for newborns.
Dobutamine and adrenaline are widely used as second line therapy for systemic hypotension in infants.
Dopamine is currently the most widely used first line drug.
In neonates, sustained hypotension may, and impaired organ perfusion will, cause brain injury and poor neurodevelopmental outcomes.
All three catecholamines are currently used off-label and have different modes of action which may result in potentially harmful haemodynamic effects.
No reliable safety or efficacy data exists for the use…
Partner organizations (coordinator is shown above), with normalized type and CORDIS activity type. Guests see up to 4 partners.
Germany, Hannover
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
Spain, Vitoria-Gasteiz
Type: Public body
Activity type: Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
SME: No
Germany, Lubeck
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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