CORDIS Project
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This project explores a novel type of kidney stem/progenitor cells derived from neonatal urine, which can differentiate into functional kidney cells. The research aims to utilize these cells for developing targeted therapies to improve kidney transplant outcomes by reducing inflammation and enhancing tissue regeneratio…
Global mortality from chronic kidney disease (CKD) is estimated at more than 1.2 million annually. CKD is caused by the irreversible loss of nephrons, the structural and functional units of the kidney.
Lineage tracing revealed that all renal cells are derived from a SIX2+ embryonic progenitor population originating at the cap mesenchyme (CM). SIX2 is essential for cells’ self-renewal, and its cessation signals the initiation of nephron differentiation.
However, SIX2+ progenitor cells are exhaust…
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Belgium, Leuven
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
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