CORDIS Project
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This project explores the activation of T cells by cancer cells in spontaneous tumors, aiming to clarify the role of immune surveillance. By using novel cancer models, it investigates how T cells respond to naturally occurring tumor antigens under resting conditions, contributing to understanding cancer immunity.
An old question in tumor immunology is whether cancer cells can spontaneously activate T cells that in turn destroy them, termed immunosurveillance.
While firmly established for virus-associated tumors, immunosurveillance of spontaneous tumors is still controversial.
Intuitively, autochthonous cancer models may be better suited than transplantation model to address this question, yet current models bear pitfalls and do not resemble the sporadic nature of human cancer.
Importantly, they are not c…
MAX DELBRUECK CENTRUM FUER MOLEKULARE MEDIZIN IN DER HELMHOLTZ-GEMEINSCHAFT (MDC)
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