CORDIS Project
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This research investigates the XPF/ERCC1 protein complex involved in DNA repair, focusing on its role in maintaining genomic stability. The study aims to understand its mechanisms and interactions, which could lead to new cancer treatment strategies.
Numerous DNA repair pathways are required for genomic stability and chromosome maintenance. XPF/ERCC1 protein complex is an evolutionally conserved structure-specific endonuclease involved in nucleotide excision repair (NER) and other DNA repair pathways, making it essential for viability.
The pleiotropic phenotypes of XPF/ERCC1 deficiency in humans range from cancer-predisposition to accelerated aging and severe developmental abnormalities.
The research outlined here combines biochemical and st…
Masarykova univerzita
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