CORDIS Project
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This project aims to develop advanced methods for studying transient protein-protein interactions using engineered antibodies. By focusing on key signaling pathways, it seeks to uncover the atomic structures of these complexes, enhancing our understanding of cellular signaling.
Although many thousands of transient protein-protein interactions (PPIs) are known, there is a disturbing paucity of high-resolution structures of the resulting complexes and the difficulties involved in experimentally determining these
atomic structures remain essentially unaddressed.The Steyaert lab has shown that cross-linking transiently interacting proteins, followed by immunization of llama’s with this cross-linked antigen, causes the maturation of single domain
antibodies called Nanobodie…
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