CORDIS Project
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NetriCan investigates the role of netrin-1 and its receptor in cancer biology, particularly their influence on the epithelial-to-mesenchymal transition in tumors. The project aims to identify new therapeutic strategies targeting this process to improve treatment outcomes for advanced solid tumors.
Recent data coming from both basic research and clinical trials converge toward the importance of the epithelial/mesenchymal status of a tumor to respond to conventional chemotherapies and immune-checkpoint inhibitors.
These observations set the Epithelial-to-Mesenchymal Transition (EMT) program at the centre of cancer biology.
Besides its multiple roles in development and during adulthood, EMT is activated during tumor progression not only to allow metastatic dissemination of cancer cells, whic…
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