CORDIS Project
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This project explores the role of platelets and neutrophils in the immune response during severe sepsis. It aims to uncover the mechanisms by which platelets activate neutrophils to trap bacteria, potentially identifying new therapeutic targets for sepsis treatment.
Despite treatment advances, sepsis kills an estimated 150,000 in the EU annually.
Lipopolysaccharide (LPS), neutrophils and platelets all participate in the pathogenesis of severe sepsis, but the inter-relationships between these players are poorly understood.
Recently, we demonstrated that activation of neutrophils by platelets is necessary to defend against bacterial infection (Clark et al, Nat Med 2007).
In response to endotoxaemia or bacteraemia, neutrophils lodged primarily in lung capillar…
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