CORDIS Project
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This research project focuses on understanding how morphogen signaling, specifically Sonic Hedgehog, influences gene expression patterns in the vertebrate neural tube. It aims to quantify signaling noise and its buffering mechanisms to elucidate developmental processes.
Morphogens are locally produced molecules that act over long distances in tissues to control the pattern of gene expression. A particularly well-understood model system for studying the mechanisms of morphogen-mediated patterning is the vertebrate neural tube.
Here, Sonic Hedgehog (Shh) induces discrete neuronal progenitor domains through regulation of a combinatorial code of transcription factors.
The observed precision and reproducibility of gene expression appears greater than can be accounte…
THE FRANCIS CRICK INSTITUTE LIMITED
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United Kingdom, LONDON
Type: Public body
Activity type: Public bodies (excluding Research Organisations and Secondary or Higher Education Establishments)
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