CORDIS Project
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This project explores the role of DNA double-strand breaks in cognitive deficits associated with neurodegenerative diseases and central nervous system infections. It aims to uncover how these breaks affect neuronal function and contribute to behavioral impairments.
Cognitive deficits are manifested several years prior detecting any neuronal loss in neurodegenerative diseases or during persistent infections of the central nervous system (CNS).
Accumulating evidence show that epigenetic alterations contribute to neuronal dysfunction, as they cause durable changes of the chromatin structure that affect gene expression.
In this context, DNA double-strand breaks (DSBs) are now emerging as central regulators of neuronal epigenetics.My recent findings opened inno…
CENTRE NATIONAL DE LA RECHERCHE SCIENTIFIQUE CNRS
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