CORDIS Project
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This research investigates the role of ultra-long 3' untranslated regions in neuronal gene regulation, particularly focusing on the RNA-binding protein ELAV in Drosophila. The study aims to understand how these extended mRNAs influence neuronal function and their implications for memory and disease.
Neurons employ cell-specific gene regulatory mechanisms.
One particularly striking process is the recently discovered, drastic lengthening of the 3’ untranslated region (3’ UTR) of hundreds of genes, which occurs in neurons from flies to humans.
The function of the resulting ultra-long 3’ UTRs is unknown. RNA deregulation plays a central role in neurological diseases; to understand underlying causes, it is essential to study regulatory processes and define the function of these novel 3’ UTRs.In…
MAX-PLANCK-GESELLSCHAFT ZUR FORDERUNG DER WISSENSCHAFTEN EV
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