CORDIS Project
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This project investigates the role of the autophagy-related gene Wdr45 in neurodevelopmental and neurodegenerative disorders using Drosophila models. By studying the effects of Wdr45 mutations, the research aims to uncover mechanisms underlying brain disorders and identify potential early biomarkers and therapeutic tar…
Understanding the fundamental basis of brain disorders is a one of the greatest challenges of the 21st century.
Large-scale genetic studies have identified numerous genes with associated roles in both neurodevelopmental and neurodegenerative disorders, suggesting that common mechanisms are involved in the different phases of the same disease.
Autophagy is such mechanism, which dysfunction during development or in adult can lead to neurodegenerative diseases, including beta-propeller protein-as…
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