CORDIS Project
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This project investigates the role of neurofilaments in neurodegeneration using zebrafish models. By studying the dynamics of neurofilament transport and degradation, the research aims to identify therapeutic interventions that could reverse neurodegenerative processes and improve neurological functions.
Neurofilaments (NFs) are a highly dynamic cytoskeletal network, which exhibits essential functions in neurons and are key actors in neurodegeneration. NFs are not only a genetic cause of neuronal death in human, their abnormal aggregation is an early pathological hallmark in disease, and their genetic removal from axons has shown spectacular benefits in delaying disease onset, extending survival and restoring neurological functions in mouse models.
In this project, I propose the concept that th…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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