CORDIS Project
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This project focuses on enhancing beta-cell replacement therapies for diabetes by investigating the role of the neurogenin3 transcription factor in promoting endocrine differentiation. It aims to identify and manipulate genes involved in intercellular signaling pathways to improve the efficiency of generating beta-cell…
To date, development of beta-cell replacement therapies for treatment of type 1 and type 2 diabetes is limited by the availability of pancreatic islets from organ donors.
Hence, alternative strategies rely on generating and expanding beta-cells in vivo or in vitro from renewable sources such as adult progenitors or stem cells, which can be coaxed to differentiate into beta-cells.
However, these strategies, based on the knowledge of in vivo embryonic beta-cell differentiation, are still inefficie…
CONSORCI INSTITUT D'INVESTIGACIONS BIOMEDIQUES AUGUST PI I SUNYER
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