CORDIS Project
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This project investigates the role of the transcription factor CREB in neural stem and progenitor cells. It aims to understand its influence on neurogenesis and potential implications for brain tumors using advanced genetic techniques.
Amongst the many factors regulating neural stem and progenitor cell (NSPC) proliferation, survival and differentiation, transcription factors are important factors governing gene expression in NSPCs.
Several recent reports indicate that the prototypical transcription factor, cyclic-AMP Element Binding protein (CREB) displays restricted constitutively activated expression in mouse brain neurogenic zones.
Germline and conditional panneuronal-specific inactivation of the Creb1 gene has shown the cr…
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