CORDIS Project
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NeurogENSity focuses on understanding the changes in the enteric nervous system associated with Inflammatory Bowel Disease. The project aims to characterize how inflammation affects neuron formation and identity, potentially leading to new treatment strategies for gastrointestinal conditions.
Inflammatory Bowel Disease (IBD) encompasses two gastrointestinal conditions - Crohn’s disease and ulcerative colitis - which currently lack satisfactory treatment. IBD is associated with alterations to the enteric nervous system (ENS) of the gut, including the formation of new neurons (‘neurogenesis’) and changes in the properties of existing neurons (‘neuroplasticity’).
Growing evidence suggests an interplay between acute inflammation and ENS pathology.
Despite this, detailed characterisation…
KAROLINSKA INSTITUTET
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