CORDIS Project
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This project investigates how neuronal cells sense their environment and migrate, focusing on the role of ubiquitin ligase E3a in neurodevelopmental disorders like autism and Angelman Syndrome. Using advanced technologies, it aims to clarify the biochemical processes involved in neuronal guidance and the impact of thes…
Defects in neuronal migration have a severe impact on normal brain function.
Here, neuronal contact sensing of the extracellular environment combines with complex signaling, determining the final wiring and plasticity.
Although deficits in neuronal micro-connectivity are recently emerging as crucial in neurodevelopmental disorders (e.g. autism, schizophrenia), the role of neuronal sensing and fine-migration processes is still poorly understood in these pathological conditions.I propose to study…
ERASMUS UNIVERSITAIR MEDISCH CENTRUM ROTTERDAM
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