CORDIS Project
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This project focuses on understanding the aggregation of alpha-synuclein protein in neurons, which is linked to Parkinson’s disease. By employing advanced imaging and spectroscopy techniques, it aims to reveal insights into the mechanisms of protein aggregation and potential therapeutic strategies.
Intracellular aggregation of the human amyloid protein alpha-synuclein is causally involved in Parkinson’s disease, a debilitating neurodegenerative disorder.
The goal of this project is to combine low-resolution, fluorescence-imaging methods with high-resolution in-cell NMR and EPR spectroscopy techniques to derive macroscopic and microscopic insights into alpha-synuclein aggregate structures directly in neuronal cells.
To achieve this goal, we will employ different sets of cultured neurons a…
WEIZMANN INSTITUTE OF SCIENCE
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Germany, Berlin
Type: Research institute
Activity type: Research Organisations
SME: No
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