CORDIS Project
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This project investigates the role of the enzyme Nicotinamide mononucleotide adenylyltransferase 1 in neuronal maintenance and neuroprotection. By creating a specific mouse model, the research aims to clarify how NMNAT1 and NMNAT2 contribute to the survival of neurons and their potential as therapeutic targets in neuro…
Nicotinamide mononucleotide adenylyltransferase (NMNAT) is the central enzyme in NAD biosynthetic pathways.
Among the three known mammalian isozymes, nuclear NMNAT1 generates NAD which is used as substrate for the enzymes SIRT1 and PARP1, involved in transcription control and DNA damage repair and associated to cell death and senescence.
Various data suggest that NMNAT1 could be neuroprotective:
SIRT1 activation or overexpression confers neuroprotection in various models of neurodegenerative dis…
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