CORDIS Project
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This project investigates RNA-binding proteins involved in neural differentiation using patient-derived stem cells. By identifying novel proteins and their binding targets, it aims to understand mechanisms behind neurodegeneration and improve therapeutic strategies for diseases like amyotrophic lateral sclerosis.
RNA-binding proteins (RBPs) coordinate post-transcriptional regulation immediately after transcription by RNA-processing, nuclear export, localization, stability and translation rate of RNAs.
The importance of these RBPs in neural development have been underscored by detecting their mutations in severe neurodegenerative diseases such as amyotrophic lateral sclerosis (ALS), ataxia or tremor.
In this project, using the assays that I developed specifically for the identification of RBPs I want to t…
THE FRANCIS CRICK INSTITUTE LIMITED
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