CORDIS Project
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This project investigates the role of two mammalian rhomboid proteases, RHBDL1 and RHBDL3, in the nervous system. It aims to identify their substrates in neurons and understand their physiological significance, contributing to our knowledge of neurobiological disorders like Alzheimer's and Parkinson's diseases.
Proteases control major pathways in the nervous system and aberrant proteolysis underlies many neurobiological disorders and diseases e.g.
Alzheimer's and Parkinson's disease.
Signal generation and release is tightly regulated by protease activity, as many key signalling factors are synthesised as transmembrane precursors that require cleavage to liberate their active ectodomains.
The largest family of intramembrane proteases are the newly discovered rhomboids, which are found in all kingdoms of…
THE CHANCELLOR, MASTERS AND SCHOLARS OF THE UNIVERSITY OF OXFORD
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