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The NeuroStemX project aims to model Fragile X syndrome by generating induced pluripotent stem cells and studying the timing of gene silencing during neural development. It seeks to establish a reliable in vitro system to understand neuronal defects associated with this condition.
Neurological and mental disorders are top priorities for the European Commission, which actively invests in research aimed at better understanding brain function and dysfunction, and at finding new therapies for brain disorders.
Fragile X syndrome (FXS) is the major monogenetic cause for intellectual disability and is frequently associated with autism spectrum disorder.
The trinucleotide repeat expansion, methylation and epigenetic silencing of fragile mental retardation 1 (FMR1) gene promoter l…
UNIVERSITA DEGLI STUDI DI PADOVA
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