CORDIS Project
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This project aims to enhance our understanding of how proteins are transported within neurons, which is crucial for synaptic function and memory. By developing new imaging tools, it will investigate the roles of molecular motors and the cytoskeleton in synaptic protein delivery.
Activity-dependent modulation of synapses is the core mechanism of synaptic plasticity and underlies learning and memory processes in the brain.
Understanding dynamic changes at synapses requires a deeper insight in the molecular machinery involved in the transport and trafficking of postsynaptic proteins.
Recent studies suggest that the cytoskeleton (microtubule and actin) and molecular motors (kinesin, dynein and myosin) play an essential role in the targeting and delivery of cargos to synapse…
UNIVERSITEIT UTRECHT
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