CORDIS Project
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This project investigates the role of ARMS/Kidins220 in the functions of neurotrophins, specifically focusing on their impact on neuronal differentiation, dendritic branching, and synaptic plasticity. The research employs biochemical, cellular, and genetic techniques to enhance understanding of neurotrophin mechanisms…
Neurotrophins are growth factors including NGF, BDNF, NT-3 and NT-4, which function in cell survival, differentiation, apoptosis, axonal and dendritic growth, and plasticity in the nervous system.
Additionally, BDNF has been implicated in human brain pathologies, such as depression, Alzheimer, Huntington, Parkinson, etc.
Neurotrophins bind to two different sets of receptors, Trk and p75 receptors, to mediate their functions.
Trk activation leads to its phosphorylation in tyrosine and the phospho…
UNIVERSIDAD DE SALAMANCA
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