CORDIS Project
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This project focuses on understanding the signaling mechanisms of the PI3-kinase pathway in cancer, particularly under conditions of nutrient starvation and hypoxia. It aims to explore new cancer therapies targeting PIK3CA mutations.
PI 3-kinase (PI3K) signalling regulates multiple cell functions and is one of the most frequently genetically-activated pathways in cancer.
This is mainly due to activating mutations in PIK3CA (the gene encoding the PI3Kα catalytic subunit) or inactivation of the tumour-suppressor PTEN (which opposes PI3K signalling).Solid tumours are most often hypoxic and nutrient-starved.
The central premise of my proposal is that PI3K signalling has thus far been predominantly investigated under experimental…
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