CORDIS Project
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This project aims to improve glycoconjugate vaccines by understanding how carbohydrate presentation enhances immune response. It focuses on developing a new platform for carbohydrate-based vaccines by analyzing variables like peptide carriers and conjugation chemistry to optimize immunogenicity.
Glycoconjugate vaccines have provided enormous health benefits globally, but they have been less successful in some populations at high risk for developing disease.
They are composed by a sugar antigen covalently linked to a carrier protein.
The traditional hypothesis of immune activation by glycoconjugate vaccines suggests that only peptides generated from glycoconjugate processing can be presented to and recognized by T cells, and this contribution is crucial for their immunogenicity.
In most…
UNIVERSITA DEGLI STUDI DI MILANO
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United States, Cambridge
Type: University / higher education
Activity type: Higher or Secondary Education Establishments
SME: No
Italy, SIENA
Type: Company (for-profit)
Activity type: Private for-profit entities (excluding Higher or Secondary Education Establishments)
SME: No
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