CORDIS Project
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This project investigates how neuronal activity influences gene expression and chromosome structure in the brain. By mapping genomic interactions and using advanced imaging techniques, it aims to uncover mechanisms that regulate learning and memory.
A remarkable feature of the brain is its ability to adapt to changing environmental conditions.
Modulation of synaptic strength and neuronal circuitry underlies experience-dependent learning, and requires widespread changes in gene expression.
Following neuronal depolarisation, intracellular signalling results in rapid induction of many activity-regulated genes (ARGs).
There are numerous interconnected levels of gene regulation; one critical aspect relates to the three-dimensional conformation…
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