CORDIS Project
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This project focuses on understanding the mechanisms of N-heterocyclic carbene (NHC) catalysis, particularly the Breslow intermediate, to improve the selection of catalysts for synthetic transformations. By providing quantitative insights into the reactivity of this key intermediate, the project aims to enhance the eff…
N-heterocyclic carbenes (NHCs) are the most versatile class of organocatalyst, allowing access to a variety of catalytic intermediates for the construction of complex targets from simple starting materials under mild conditions.
Despite many individual conceptual advances in this field, it is not understood (or even commonly acknowledged by practitioners) why product distributions of NHC-catalysed processes often differ dramatically with catalyst scaffold or with subtle substituent variation wit…
THE UNIVERSITY COURT OF THE UNIVERSITY OF ST ANDREWS
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