CORDIS Project
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This project focuses on the segmented filamentous bacteria and its role in gut immune system development. It aims to understand the interactions between this bacterium and host cells using advanced culturing techniques and microscopy.
The gut microbiota plays an integral part in driving the postnatal maturation of the gut immune system and in protecting the host from pathogens.
The commensal segmented filamentous bacteria (SFB) plays a critical role in these processes through its intimate attachment to the ileal epithelium using a unique pointed tip structure on its unicellular infectious particle. SFB induces a broad pro-inflammatory immune activation, and notably a striking induction of IgA and Th17 cell responses, that fos…
INSTITUT NATIONAL DE LA SANTE ET DE LA RECHERCHE MEDICALE
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