CORDIS Project
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This project investigates how the structure of nuclear pore complexes affects the differentiation of mesenchymal stem cells. By creating synthetic culture environments, it aims to understand the mechanotransduction processes that govern stem cell behavior, potentially advancing regenerative medicine and tissue repair t…
Many therapeutic applications of stem cells require accurate control of their differentiation.
To this purpose there is a major ongoing effort in the development of advanced culture substrates to be used as “synthetic niches” for the cells, mimicking the native ones.
The goal of this project is to use a synthetic niche cell culture model to test my revolutionary hypothesis that in stem cell differentiation, nuclear import of gene-regulating transcription factors is controlled by the stretch of t…
POLITECNICO DI MILANO
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