CORDIS Project
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This research project investigates how mesenchymal colorectal cancers (CRCs) achieve self-sustained growth through a process called niche-mimicry, where cancer cells adopt features of their surrounding environment. By studying primary human CRC models, the project aims to uncover the signaling mechanisms that contribut…
Colorectal cancer (CRC) is a heterogeneous disease with widely variable clinical outcomes. I previously contributed to a unifying molecular classification of CRC, the consensus molecular subtypes (CMSs).
The mesenchymal subtype (CMS4), representing ~25% of all CRC patients, is characterised by early metastatic dissemination and poor response to therapy.
This is often attributed to activated and rich stroma and therefore much attention in the field goes to dissecting the interaction of the mesenc…
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