CORDIS Project
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This project investigates how the bacterium Pseudomonas aeruginosa senses mechanical forces and how these forces influence its virulence. By studying the protein PilY1, the research aims to develop strategies to disrupt its mechanotransduction pathway, potentially leading to new therapeutic approaches against bacterial…
Mechanical force is a ubiquitous perturbation that operates at all levels of life, from single molecules to organs.
At the tissue level, cells are constantly exposed to forces exerted by their surrounding environment—body fluids, neighboring cells, or the extracellular matrix.
The process by which cells sense and convert physical stimuli into a biochemical signal is known as mechanotransduction.
When mechanical forces reach the nucleus, they can activate several force-induced transcriptional pat…
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