CORDIS Project
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This project investigates the role of the NKG2D receptor in CD4+ T cells related to inflammatory bowel disease and rheumatoid arthritis. Using mouse models and human cell analysis, it aims to clarify how NKG2D signaling affects T cell responses and contributes to autoimmune inflammation.
More than 5 million people in Europe live with inflammatory bowel disease (IBD) or rheumatoid arthritis (RA).
Both diseases are characterized by chronic inflammation partially mediated by inappropriate T cell response.
Effector T-cell responses can be modulated by competing positive or negative costimulatory signals, and dysregulated balance between these signals may lead to chronic autoimmune inflammation.
In mice, within the CD4+ T cell population, the expression of NKG2D is primarily associat…
DEUTSCHES RHEUMA FORSCHUNGSZENTRUMBERLIN
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