CORDIS Project
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This research investigates the role of the NR3A subunit of the NMDA receptor in synapse pruning during brain development. It aims to understand how abnormal NR3A expression is linked to cognitive deficits in mental disorders and to identify potential therapeutic targets.
The aim of the project is to understand how the NMDA receptor subunit NR3A is involved in selective synapse elimination (“pruning”) during development and how the abnormal expression of NR3A found in mental disorders such as Schizophrenia, Alzheimer´s disease and Huntington correlates with the reduction of functional synapses and deficits in the cognitive function.
Importantly, the Host lab has already proved that restoring the normal NR3A expression levels reverses both, the spine lost and the…
FUNDACION PARA LA INVESTIGACION MEDICA APLICADA FIMA
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