CORDIS Project
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This project investigates the molecular structure and dynamics of neuromuscular junctions (NMJ) in the context of amyotrophic lateral sclerosis (ALS). By utilizing zebrafish models and advanced imaging techniques, the study aims to identify key proteins involved in NMJ stability, potentially leading to new therapeutic…
Amyotrophic lateral sclerosis (ALS) is a late onset, lethal neurodegenerative disease of motor neurons that affects about 2 in 100,000 individuals per year.
Different genetic mutations have been described in patients, but the genes involved seem unrelated and the causes of the disease appear complex and are still largely not understood.
Of relevance, the destabilisation of neuromuscular junctions (NMJ) may be an early event, preceding neuronal death, making them an interesting therapeutic target…
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