CORDIS Project
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This project explores the role of soluble guanylate cyclase in nitric oxide signaling, aiming to enhance drug design by understanding its structure and dynamics. It combines NMR spectroscopy and computational methods to identify new compounds that activate this key protein.
Gas-sensing proteins play an important role in mediating biological events.
Soluble guanylate cyclase (sGC) is activated when nitric oxide (NO) binds to heme Fe of sGC, and then stimulates cyclization of guanosine 5-triphosphate (GTP) to the second messenger cyclic guanosine 3,5-monophosphate (cGMP), which in turn has a direct role in the control of a variety of physiological processes in several signal transduction pathways.
Disruptions in the NO/sGC/cGMP signalling pathway have been linked to…
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